Reference systems and frames are of primary importance for many Earth science applications, satellite navigation as well as for practical applications in geo-information. A precisely defined reference frame is needed for the quantification of, e.g. Earth rotation and its gravity field, global and regional sea level variation, tectonic motion and deformation, post-glacial rebound, geocenter motion, large scale deformation due to Earthquakes, local subsidence and other ruptures and crustal dislocations. All of these important scientific applications fundamentally depend on a truly global reference system that only space geodesy can realize. This volume details the proceedigns of the IAG Symposium REFAG2010 (Marne la Vallée, France, October 4-8, 2010) The primary scope of REFAG2010 was to address today achievements on theoretical concepts of reference systems and their practical implementations by individual space geodetic techniques and their combinations, underlying limiting factors, systematic errors and novel approaches for future improvements.