This book provides a hands-on experience in software and hardware engineering of IoT devices in edge and cloud computing systems, by putting in practice state-of-the-art concepts of hardware devices, networking and computing software. It proposes a Network of Things Engineering (NoTE) Lab, with seven hands-on lab modules covering topics ranging from “Interfacing sensors and actuators� and “Connecting IoT and Edge with MQTT" to “Data pipelining in cloud computing�. All tools and software used in the NoTE Lab are free and open source, and available to the readers. Specifically, Arduino-based boards that support a variety of low-cost sensors and actuators are used in IoT context. In edge computing, NoTE Lab implements off-the-shelf single board computers, Raspberry Pis with corresponding software and hardware. For cloud, well-known and widely used cloud computing open-source tools (e.g., Kubernetes) are deployed, where readers can learn the basics of monitoring and managing containersin cloud computing. Three communication protocols are used in the end-to-end setup, including MQTT, AMQP and HTTP. This lab book is a "must experiment with" for anybody in academia and industry participating in the fascinating IoT-edge-cloud continuum development.