This comprehensive analysis of U.S. policy toward the Armenian Question and the Armenian Genocide focuses on the important role big business played in keeping the United States from playing a more active role in opposing the genocide, notwithstanding broad public opinion calling for greater action. Business interests feared antagonizing the Turkish leaders by too much of an intervention on behalf of the Armenians. It surveys the historical evolution of U.S. policy toward the Ottoman Empire since the early nineteenth century and examines the extent to which the missionary community, commercial interests, and international economic and geopolitical competitions shaped U.S. policy during the administrations of William McKinley, Theodore Roosevelt, William Howard Taft and Woodrow Wilson.