The two-volume set LNICST 587 + 588 constitutes the refereed proceedings of the EAI 15th International Conference on nternational Conference on e-Infrastructure and e-Services for Developing Countries, AFRICOMM 2023, which took place in Bobo-Dioulasso, Burkina Faso, in November 2023. The 59 full papers  presented in these two volumes were carefully reviewed and selected from 72 submissions. The papers are organized in the following topical sections: Part I: Digital economy, Digital transformation, e-Government and e-services; ICT infrastructures for critical environmental conditions; Wireless networks; E-health; Cybersecurity and Privacy. Part II: Systems and cloud computing; Artificial Intelligence; Ontology and data preparation; Responsible Artificial Intelligence for Sustainable Development in Africa (workshop).