This book constitutes the refereed proceedings of the 22nd International Conference on Theory and Applications of Satisfiability Testing, SAT 2019, held in Lisbon, Portugal, UK, in July 2019. The 19 revised full papers presented together with 7 short papers were carefully reviewed and selected from 64 submissions. The papers address different aspects of SAT interpreted in a broad sense, including (but not restricted to) theoretical advances (such as exact algorithms, proof complexity, and other complexity issues), practical search algorithms, knowledge compilation, implementation-level details of SAT solvers and SAT-based systems, problem encodings and reformulations, applications (including both novel application domains and improvements to existing approaches), as well as case studies and reports on findings based on rigorous experimentation.