The book examines the supply chain from different perspectives: the physical structure which it is composed of (actors, roles, infrastructures and processes), the organizational structure of the people involved (business functions and related interactions and integrations), and the manifold flows that characterize it (product flows, information flows, service flows and monetary flows). For each of these dimensions, the text thoroughly illustrates how to design and manage it, aligning supply chain performance and competitive strategies through an integrated approach, which is key to generate competitive advantage. The book covers the different topics by combining a quantitative approach typical of engineering disciplines and adopted particularly in the operational parts, with a qualitative approach which fits in the more strategic parts. This combination makes the volume suitable for both under- and post-graduate students in industrial engineering and management, as well as undergraduates or masters students confronting supply chain management from different cultural backgrounds. Industry operators and practitioners can also find useful insights, since it thoroughly describes industry best practices, especially in the food and consumer goods, fashion and apparel, pharmaceutical and healthcare sectors, stemming from author real life experiences in these fields.