In 2020, the National Survey on Drug Use and Health estimated that 40.3 million Americans met the criteria for a substance use disorder (SUD) in the past year. Yet few FDA-approved treatments exist for SUDs—and no explicit treatment guidelines. When it comes to multi-SUDs in particular, the dearth of literature is notable.This is where Pharmacotherapy for Complex Substance Use Disorders: A Practical Guide comes in. Fifteen addiction psychiatrists have contributed to this volume, bringing their clinical experience to bear for readers that include mental health and primary care clinicians.Introductory chapters provide a necessary framework, offering an overview of SUDs; general guidelines for taking a history, making a medical and a psychiatric evaluation, and forming a diagnosis; and a discussion of the neurobiology of addiction. In the subsequent chapters, the volume delves into maintenance pharmacological treatment for co-occurring substances that include • Alcohol• Opioids• Psychostimulants• Novel psychoactive substances Uniquely, this guide also discusses psychopharmacological approaches to working with special patient populations—adolescents, LGBTQ+ individuals, and pregnant people among them.Filled with tables for ease of reference both when diagnosing and treating patients, and bolstered by evidence-based, actionable information, Pharmacotherapy for Complex Substance Use Disorders: A Practical Guide sets itself apart as an indispensable resource for all providers aiding individuals on their journeys of recovery.