This book offers up-to-date research on genome editing and omics technologies from renowned academics with established backgrounds from throughout the globe. The world population is expected to touch 9–10 billion by 2050 and to feed the growing population, 50% more food must be produced globally than is currently produced. Nonetheless, it is a difficult challenge to increase the food output of the currently existing crops on available land. Over the past few decades, traditional crop enhancement techniques like plant breeding and other agricultural technology have made a significant contribution to food and nutritional security. With the use of strong technologies, genome editing strategies can significantly improve the productivity and efficiency of current agricultural practices. Discovering the underlying mechanisms influencing features of economic value has been made possible through genome editing through CRISPR/Cas9, primer and base editing, and OMICs through genomics, proteomics, metabolomics, transcriptomics, and phenomics. This book provides a wealth of information on omics and genome editing approaches and their application to develop abiotic, biotic, and climate-tolerant crops, as well as RNA interference, next-generation sequencing, and metabolomics for sustainable crop production. Researchers are actively using both genome editing and omics for crop improvement; however, there is limited literature offered in a single source. Undergraduate and postgraduate students, researchers, policymakers, and stakeholders will find this book to be an invaluable resource.