This proceedings book includes a selection of refereed papers presented at the International Conference on Modern Mechanics and Applications (ICOMMA) 2020, which took place in Ho Chi Minh City, Vietnam, on December 2–4, 2020. The contributions highlight recent trends and applications in modern mechanics. Subjects covered include biological systems; damage, fracture, and failure; flow problems; multiscale multi-physics problems; composites and hybrid structures; optimization and inverse problems; lightweight structures; mechatronics; dynamics; numerical methods and intelligent computing; additive manufacturing; natural hazards modeling. The book is intended for academics, including graduate students and experienced researchers interested in recent trends in modern mechanics and application.