This book presents endeavors to join synergies in order to create added value for society, using the latest scientific knowledge to boost technology transfer from academia to industry. It potentiates the foundations for the creation of knowledge- and entrepreneurial cooperation networks involving engineering, innovation, and entrepreneurship stakeholders. The Regional HELIX 2018 conference was organized at the University of Minho School of Engineering by the MEtRICs and Algoritmi Research Centers, and took place in Guimarães, Portugal, from June 27th to 29th, 2018. After a rigorous peer-review process, 160 were accepted for publication, covering a wide range of topics, including Control, Automation and Robotics; Mechatronics Design, Medical Devices and Wellbeing; Cyber-Physical Systems, IoT and Industry 4.0; Innovations in Industrial Context and Advanced Manufacturing; New Trends in Mechanical Systems Development; Advanced Materials and Innovative Applications; Waste to Energy and Sustainable Environment; Operational Research and Industrial Mathematics; Innovation and Collaborative Arrangements; Entrepreneurship and Internationalization; and Oriented Education for Innovation, Engineering and/or Entrepreneurship.