This book constitutes the refereed proceedings of the Second International Conference on Information Systems for Crisis Response and Management in Mediterranean Countries, ISCRAM�med 2015, held in Tunis, Tunisia, in October 2015.   The objectives of the ISCRAM�med conference are to provide an outstanding opportunity and an international forum for local and international researchers, practitioners, and policy makers to address and discuss new trends and challenges with respect to information systems for crisis response and disaster management.  The 14 full papers and 4 short papers presented in this volume were carefully reviewed and selected from 41 submissions. They are organized in topical sections on social computing, modeling and simulation, information and knowledge management, engineering of emergency management systems, and decision support systems and collaboration.