Histone Recognition - E-book

eBook

Histone Recognition - ENG

eBook

$2,980.00

Disponible

Información adicional
Sinopsis

ISBN:	9783319181028
Formato:	Page Fidelity
Idioma:	Inglés
Editorial:	Springer Nature
Tema:	Medicina
Subtema:	Genética
Año de publicación:	2015-05-29

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

eBooks