The fourth edition of this leading book provides an authoritative, comprehensive and complete account of the neuronal disorders of the lower gastrointestinal tract in children. The book has been thoroughly revised and updated to reflect major advances that have occurred both in the understanding as well as the treatment of Hirschsprung disease.  Contents discuss the latest therapies such as stem cell therapies, the epidemiology and association with multiple endocrine neoplasia and approaches to diagnosis such as radiology and manometry as well as Hirschsprung disease in adolescents and adults. Surgical approaches are thoroughly covered and include a new chapter on intestinal transplantation options. The follow-up care and long-term outcomes of patients who have undergone therapy are also addressed in this edition. With several new chapters added and the contents updated and re-worked, this edition is authored by the leading current experts in their respective fields. It is a must-have book for pediatric surgeons, pediatricians, gastroenterologists, and colorectal surgeons.