Heteroaromatic Lipoxin A4 Analogues - E-book

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Heteroaromatic Lipoxin A4 Analogues - ENG

Synthesis And Biological Evaluation

Colm Duffy

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Sinopsis

ISBN:	9783642246326
Formato:	ePub
Idioma:	Inglés
Editorial:	Springer Nature
Tema:	Ciencia
Subtema:	Química orgánica
Año de publicación:	2012-01-10

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work inÂ the synthesis of further heteroaromatic analogues for biological evaluation.

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