The updated and expanded third edition of this book focuses on the multi-disciplinary coupling between flight-vehicle hardware alternatives and enabling propulsion systems. It discusses how to match near-term and far-term aerospace vehicles to missions and provides a comprehensive overview of the subject, directly contributing to the next-generation space infrastructure, from space tourism to space exploration. This holistic treatment defines a mission portfolio addressing near-term to long-term space transportation needs covering sub-orbital, orbital and escape flight profiles. In this context, a vehicle configuration classification is introduced covering alternatives starting from the dawn of space access. A best-practice parametric sizing approach is introduced to correctly design the flight vehicle for the mission. This technique balances required mission with the available vehicle solution space and is an essential capability sought after by technology forecasters and strategic planners alike.