The main topics of this volume, dedicated to Lance Littlejohn, are operator and spectral theory, orthogonal polynomials, combinatorics, number theory, and the various interplays of these subjects. Although the event, originally scheduled as the Baylor Analysis Fest, had to be postponed due to the pandemic, scholars from around the globe have contributed research in a broad range of mathematical fields. The collection will be of interest to both graduate students and professional mathematicians. Contributors are: G.E. Andrews, B.M. Brown, D. Damanik, M.L. Dawsey, W.D. Evans, J. Fillman, D. Frymark, A.G. García, L.G. Garza, F. Gesztesy, D. Gómez-Ullate, Y. Grandati, F.A. Grünbaum, S. Guo, M. Hunziker, A. Iserles, T.F. Jones, K. Kirsten, Y. Lee, C. Liaw, F. Marcellán, C. Markett, A. Martinez-Finkelshtein, D. McCarthy, R. Milson, D. Mitrea, I. Mitrea, M. Mitrea, G. Novello, D. Ong, K. Ono, J.L. Padgett, M.M.M. Pang, T. Poe, A.Sri Ranga, K. Schiefermayr, Q. Sheng, B. Simanek, J. Stanfill, L. Velázquez, M. Webb, J. Wilkening, I.G. Wood, M. Zinchenko.