Fatty Acid and Lipotoxicity in Obes - E-book

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Fatty Acid And Lipotoxicity In Obesity And Diabetes - ENG

Novartis Foundation Symposium

Gregory R. Bock; Jamie A. Goode

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Sinopsis

ISBN:	9780470985564
Formato:	Page Fidelity
Idioma:	Inglés
Editorial:	Wiley Global Research (STMS)
Tema:	Medicina
Subtema:	Endocrinología y Metabolismo
Año de publicación:	20080311

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic Î² cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and Î² cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

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