In an era defined by volatility, complexity, and uncertainty, educating future-oriented change agents is essential to address pressing societal challenges such as climate change and the transition to a circular economy. These change agents play a pivotal role in driving societal transformation, requiring a mindset and skills suited to navigating complex problems and adapting to environments full of uncertainty. Entrepreneurial education emerges as a critical lever in fostering such capabilities, integrating seamlessly into higher education and lifelong learning contexts to prepare change agents for active, constructive participation in societal transitions. This book introduces a design-science research approach to entrepreneurial education, emphasizing the design, implementation, and evaluation of educational practices tailored to diverse contexts. Real-life case studies illustrate how the design-science approach has been successfully applied, offering practical insights for educators and researchers aiming to enhance their own research and teaching practices. By connecting theory to practice, the design-science approach offers a fresh perspective on entrepreneurial education. It not only unpacks the mechanisms behind effective program design but also fosters innovation through continuous, data-driven cycles of collecting and processing feedback. This approach ultimately enables the development of evidence-based entrepreneurial education that prepares change agents capable of driving the necessary societal transformation across contexts.