Cholesterol and Presynaptic Glutama - E-book

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Cholesterol And Presynaptic Glutamate Transport In The Brain - ENG

Tatiana Borisova

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Sinopsis

ISBN:	9781461477594
Formato:	ePub
Idioma:	Inglés
Editorial:	Springer Nature
Tema:	Ciencia
Subtema:	Ciencias de la Vida neurociencia
Año de publicación:	2013-07-06

Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number ofÂ neurological and neurodegenerative disorders.Â Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport whileÂ unbalanced levels ofÂ cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity.Â Â Â In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits.â€‹

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