This book constitutes the refereed proceedings of the 15h International Symposium on Business Modeling and Software Design, BMSD 2025, which took place in Milan, Italy, during July 1-3, 2025.  The 9 full papers and 14 short papers included in these proceedings were carefully reviewed and selected from 48 submissions. BMSD is a leading international forum that brings together researchers and practitioners interested in business modeling and its relation to software design. Particular areas of interest are: Business Processes and Enterprise Engineering, Business Models and Requirements, Business Models and Services, Business Models and Software, Information Systems Architectures and Paradigms, Data Aspects in Business Modeling and Software Development, Blockchain-Based Business Models and Information Systems, IoT and Implications for Enterprise Information Systems.