The general scope of the book covers diverse areas of fuzzy systems, soft computing, AI tools such as uncertain computation, decision-making under imperfect information, deep learning, and others. The topics of the papers include theory and application of Soft Computing, Neuro-Fuzzy Technology, Intelligent Control, Deep Learning-Machine Learning, Fuzzy Logic in Data Analytics, Evolutionary Computing, Fuzzy logic and Artificial Intelligence in Engineering, Social Sciences, Business, Economics, Material Sciences, and others. This book presents the proceedings of the 16th International Conference on Applications of Fuzzy Systems, Soft Computing, and Artificial Intelligence Tools, ICAFS-2022, held in Budva, Montenegro, on August 26-27, 2022. This is a useful guide for academics, practitioners, and graduates in fields of fuzzy logic and soft computing. It allows for increasing of interest in development and applying of these paradigms in various real-life fields.